Author

Daniel Álvarez Sirvent

Vrije Universiteit Amsterdam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:fine-mapping· 2 Assay:GWAS summary statistics· 1 Approach:matrix factorization· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Alex SalazariD· 3 shared Henne H. HolstegeiD· 3 shared Marc HulsmaniD· 3 shared Natasja M. van SchooriD· 3 shared Niccoló TesiiD· 3 shared Sven J. van der LeeiD· 3 shared Betty Marije TijmsiD· 2 shared Eva M. M. StrijbisiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Alex SalazarORCID

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3 papers

Recent·Most cited

Fine-mapping HLA-II haplotypes in Alzheimer's disease and healthy longevity reveals distinct associations with microglial HLA-II load and neuropathology

Daniel Álvarez Sirvent, Maruelle C. Luimes, Niccoló Tesi, Susan Karijn Rohde, Alex Salazar, Lotte J Bijker, Natasja M. van Schoor, Betty Marije Tijms, Everard G.B. Vijverberg, Eva M. M. Strijbis, Eric Hoekstra, The Netherlands Brain Bank, Inge R. Holtman, Sven J. van der Lee, Marc Hulsman, Henne H. Holstege

medRxiv · Oct 9, 2026 · PreprintGenetic & Genomic Medicine

Long-read sequencing reveals hidden structural complexity within Alzheimers disease-associated GWAS loci

Niccoló Tesi, Alex Salazar, Gerard A. Bouland, Daniel Álvarez Sirvent, Yaran Zhang, Lydian Knoop, Natasja M. van Schoor, Martijn A. Huisman, Sanduni Wijesekera, Jana Křížová, Betty Marije Tijms, Everard G.B. Vijverberg, ADGC, Bonn, CHARGE, EADB, EADI, FinnGen, GERAD, GR@ACE/DEGESCO, PGC-ALZ, Marc Hulsman, Sven J. van der Lee, , Henne H. Holstege

The paper uses long-read sequencing to uncover structural complexity in Alzheimer's disease GWAS loci, showing that lead SNPs often miss key regulatory variants.

medRxiv · Aug 17, 2026 · PreprintGenetic & Genomic Medicine

Cognitively healthy centenarians are characterized by lower frequencies of six disease-associated HLA alleles

Daniel Álvarez Sirvent, Niccoló Tesi, Marc Hulsman, Alex Salazar, Natasja M. van Schoor, Martijn A. Huisman, Yolande A.L. Pijnenburg, Wiesje M. van der Flier, Eva M. M. Strijbis, Bernard M.J. Uitdehaag, Marcel J. T. Reinders, Sven J. van der Lee, Henne H. Holstege

The paper identifies six HLA alleles associated with reduced likelihood of becoming a cognitively healthy centenarian, revealing pleiotropic effects on disease susceptibility and longevity.

medRxiv · Mar 30, 2025 · PreprintGenetic & Genomic Medicine