The paper identifies microglial states associated with Parkinson's disease genetic risk and Lewy body pathology using single-cell profiling and integrates data with AMP PD.

medRxiv · Oct 28, 2026 · PreprintGenetic & Genomic Medicine

Fine-mapping HLA-II haplotypes in Alzheimer's disease and healthy longevity reveals distinct associations with microglial HLA-II load and neuropathology

Daniel Álvarez Sirvent, Maruelle C. Luimes, Niccoló Tesi, Susan Karijn Rohde, Alex Salazar, Lotte J Bijker, Natasja M. van Schoor, Betty Marije Tijms, Everard G.B. Vijverberg, Eva M. M. Strijbis, Eric Hoekstra, The Netherlands Brain Bank, Inge R. Holtman, Sven J. van der Lee, Marc Hulsman, Henne H. Holstege

medRxiv · Oct 9, 2026 · PreprintGenetic & Genomic Medicine

Cell type-specific histone acetylation landscape in Alzheimer's disease reveals a putative role of MITF in microglia

Charbel Gergian, Paulina Urbanaviciute, Philippa M. Wells, Janis Lisa Transfeld, Aydan Askarova, Reuben M Yaa, Yukyee Wu, Kevin Chris Ziegler, Christian K. Nickl, Martina P. Pasillas, Johannes C. M. Schlachetzki, Inge R. Holtman, Peter T. Nelson, Robert A. Rissman, James B. Brewer, , Alexi Nott

This study identifies cell-type-specific histone acetylation changes in Alzheimer's disease, highlighting MITF's potential role in microglial dysfunction.

bioRxiv · Sep 14, 2026 · PreprintNeuroscience

Dynamic interplay of polygenic risk across brain disorders, neuropathological endophenotypes, and neuropsychiatric symptoms

Nienke Mekkes, Umesh Kumar, Eric Hoekstra, Alejandro Marmolejo-Garza, Ekaterina Dagkesamanskaia, Dennis D. Wever, Minke de Groot, Karim L. Kreft, Ana Rajicic, Harro Seelaar, Laura Donker Kaat, John Cornelis Van Swieten, Sanne Vermorgen, Annemieke J.M. Rozemüller, Nina L. Fransen, , Inge R. Holtman

The paper integrates genotype, clinical, and neuropathological data from 2,553 donors to show genetic risk overlaps across brain disorders and neuropsychiatric symptoms.

medRxiv · Jul 2, 2026 · PreprintGenetic & Genomic Medicine

Notch Signaling Drives Pro-Regenerative and Migratory Traits in Glandular Stem/Progenitor Cells

Davide Cinat, Rufina Maturi, Jeremy P Gunawan, Anne L. Jellema-de Bruin, Laura Kracht, Paola Serrano Martinez, Yi Wu, Abel Soto-Gamez, Marc‐Jan van Goethem, Inge R. Holtman, Sarah A. Pringle, Lara Barazzuol, Robert Paul Coppes

The paper identifies Notch signaling as essential for maintaining stem/progenitor cell self-renewal and migration post-irradiation in salivary and other gland organoids.

The EMBO Journal · Nov 5, 2025Peer-reviewedCell Biology

Fine-mapping reveals four TMEM106B haplotypes associated with neurodegenerative risk and preserved cognition at extreme age

Alex Salazar, Niccoló Tesi, Lydian Knoop, Natasja M. van Schoor, Martijn A. Huisman, Betty Marije Tijms, Everard G.B. Vijverberg, Sven J. van der Lee, Sanduni Wijesekera, Jana Křížová, Mikko Hiltunen, Markus Daμμe, Leonard Petrucelli, Marcel J. T. Reinders, Anke A. Dijkstra, , Henne H. Holstege

medRxiv · Feb 2, 2025 · PreprintGenetic & Genomic Medicine

Radiotherapy induces persistent innate immune reprogramming of microglia into a primed state

Daniëlle C. Voshart, Takuya Oshima, Yuting Jiang, Gideon P. van der Linden, Anna P. Ainslie, Luiza Reali Nazario, Fleur van Buuren-Broek, Ayla C. Scholma, Hilmar R. J. van Weering, Nieske Brouwer, Jeffrey Sewdihal, Uilke Brouwer, Robert Paul Coppes, Inge R. Holtman, Bart J. L. Eggen, , Lara Barazzuol

This study shows that radiotherapy primes microglia in rats to have a heightened immune response to future inflammation, and this effect is observed in human brain tissue.

Cell Reports · Feb 1, 2024Peer-reviewedNeuroscience

Mechanisms underlying divergent responses of genetically distinct macrophages to IL-4

Marten A. Hoeksema, Zeyang Shen, Inge R. Holtman, An Zheng, Nathan J. Spann, Isidoro Cobo, Melissa Gymrek, Christopher K. Glass

The paper identifies how non-coding genetic variation affects macrophage responses to IL-4 by analyzing SNP and InDel effects across five inbred mouse strains.

Science Advances · Jun 16, 2021Peer-reviewedGenomics

Cell type-specific enhancer-promoter connectivity maps in the human brain and disease risk association

Alexi Nott, Inge R. Holtman, Nicole G. Coufal, Johannes C. M. Schlachetzki, Miao Yu, Rong Hu, Claudia Z. Han, Monique Pena, Jiayang Xiao, Yin Wu, Zahara Keulen, Martina P. Pasillas, Carolyn O’Connor, Simon T. Schafer, Zeyang Shen, , Christopher K. Glass

The paper identifies cell type-specific enhancer-promoter connectivity in the human brain and links these to disease risk variants in Alzheimer's and psychiatric disorders.

bioRxiv · Sep 22, 2019 · PreprintNeuroscience