Author

Daniel A Keedy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Assay:cryo-EM· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Henry van den Bedem· 2 shared James Fraser· 2 shared Aaron S Brewster· 1 shared Aina E Cohen· 1 shared Ana Gonzalez· 1 shared Andrew H Van Benschoten· 1 shared Axel T Brunger· 1 shared Elizabeth L Baxter· 1 shared

Activity by Year

2015-2015 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiophysics

Henry van den Bedem

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2 papers

Recent·Most cited

Exposing hidden alternative backbone conformations in X-ray crystallography using qFit

Daniel A Keedy, James Fraser, Henry van den Bedem

This paper introduces qFit, a method to identify hidden alternative backbone conformations in X-ray crystallography, revealing peptide flips and glycine movements in HIV protease.

PLOS Computational Biology · Oct 27, 2015Peer-reviewedBiophysics

Mapping the Conformational Landscape of a Dynamic Enzyme by XFEL and Multitemperature Crystallography

Daniel A Keedy, Lillian R Kenner, Matthew Warkentin, Rahel Woldeyes, Michael C Thompson, Aaron S Brewster, Andrew H Van Benschoten, Elizabeth L Baxter, Jesse B Hopkins, Monarin Uervirojnangkoorn, Scott E McPhillps, Jinhu Song, Roberto Alonso-Mori, James M Holton, William I Weis, , James Fraser

This study uses XFEL and multitemperature crystallography to analyze the conformational changes in cyclophilin A, revealing temperature-dependent conformational heterogeneity and a conformation shuffling model.

eLife · Sep 30, 2015Peer-reviewedBiophysics