Mapping the Conformational Landscape of a Dynamic Enzyme by XFEL and Multitemperature Crystallography
Daniel A Keedy, Lillian R Kenner, Matthew Warkentin, Rahel Woldeyes, Michael C Thompson, Aaron S Brewster, Andrew H Van Benschoten, Elizabeth L Baxter, Jesse B Hopkins, Monarin Uervirojnangkoorn, Scott E McPhillps, Jinhu Song, Roberto Alonso-Mori, James M Holton, William I Weis, , James Fraser
This study uses XFEL and multitemperature crystallography to analyze the conformational changes in cyclophilin A, revealing temperature-dependent conformational heterogeneity and a conformation shuffling model.
eLife · Sep 30, 2015Peer-reviewedBiophysics