Microdroplet screening rapidly profiles a biocatalyst to enable its AI-assisted engineering
Maximilian Gantz, Simon V. Mathis, Friederike E. H. Nintzel, Matthew Penner, Paul Jannis Zurek, Tanja Knaus, Vasilis Tseliou, Elie Patel, Daniel Boros, Friedrich-Maximilian Weberling, Matthew R. A. Kenneth, Oskar James Klein, Elliot J. Medcalf, Jacob Moss, Michael Herger, , Florian Hollfelder
The paper combines microfluidic screening with machine learning to rapidly engineer biocatalysts, achieving 23-fold improvement in catalytic efficiency through sequence-function mapping.
bioRxiv · Apr 8, 2024 · PreprintSynthetic Biology