Michael Herger

PETRA quantifies regulatory variant effects by editing transcribed regions and measuring mRNA expression changes in human cells.

This paper introduces a pooled prime editing platform in haploid human cells to assess the functional effects of genetic variants, showing high accuracy in identifying loss-of-function variants and pathogenic non-coding variants.

The paper combines microfluidic screening with machine learning to rapidly engineer biocatalysts, achieving 23-fold improvement in catalytic efficiency through sequence-function mapping.

This study shows that Plakoglobin regulates naive pluripotency in mouse ESCs through mechanosensitivity, with expression specific to the blastocyst stage in human and mouse embryos.