Glutamatergic adaptation to stress in medial prefrontal cortex underlies risk and resilience for pessimistic beliefs
Jessica A. Cooper, Makiah R. Nuutinen, Victoria M. Lawlor, Brittany A. M. DeVries, Elyssa M Barrick, Shabnam Hossein, Daniel C. Cole, Chelsea V. Leonard, Andrew P. Teer, Grant S. Shields, George M. Slavich, Döst Öngür, John Eric Jensen, Fei Du, Diego A. Pizzagalli, Michael Tilghman Treadway
The paper examines stress-induced changes in mPFC glutamate using MRS in humans and finds disrupted glutamatergic adaptation in MDD associated with pessimistic beliefs.
bioRxiv · Jun 3, 2020 · PreprintNeuroscience