Post-COVID impairment of memory T cell responses to community-acquired pathogens can be rectified by activating cellular metabolism
Daniel D. Carroll, Kamacay Cira, Jack Archer, Jason W. Shapiro, Ue-Yu Pen, David A. Tieri, Lucia Leonor, Neda Dalil Roofchayee, Samantha S Yee, Marc Wahab, Igor Jerome Koralnik, John C. Alverdy, Arjun S. Raman, Lavanya Visvabharathy
This study shows that post-COVID-19 mitochondrial dysfunction impairs T cell memory responses to pathogens, but can be improved with metformin and ubiquinol.
bioRxiv · Jan 2, 2026 · PreprintImmunology