Lavanya Visvabharathy

IL-6R blockade with tocilizumab disrupts pericyte-and tumor cell-driven IL-6/STAT3 signaling, enhancing docetaxel efficacy in ER+ breast cancer

This study shows that tocilizumab enhances docetaxel efficacy in ER+ breast cancer by blocking IL-6/STAT3 signaling driven by pericytes and tumor cells.

Post-COVID impairment of memory T cell responses to community-acquired pathogens can be rectified by activating cellular metabolism

This study shows that post-COVID-19 mitochondrial dysfunction impairs T cell memory responses to pathogens, but can be improved with metformin and ubiquinol.