Adaptive Responses Directed by CREB Control Epithelial-Mesenchymal Plasticity in Cancer
Kshitij Parag‐Sharma, Harish Shrikrishna Bharambe, John Joseph Powers, Weida Gong, Daniel J. Purcell, Caleb Mensah, Chloe Twomey, Jay H. Mehta, Samy Lamouille, Antonio L. Amelio
The paper identifies CREB as a master transcription factor controlling E/M plasticity in cancer, revealing its role in hybrid E/M states and metastasis through regulation of VGLL3 and KLF3.
bioRxiv · Dec 11, 2025 · PreprintCell Biology