Genes adapt to outsmart gene targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation
Vishnu Hosur, Benjamin E. Low, Daniel Li, Grace A. Stafford, Vivek Kohar, Leonard D. Shultz, Michael V. Wiles
The paper shows that gene disruption strategies in mice can lead to unexpected exon skipping and translation, resulting in gain-of-function alleles instead of null phenotypes.
Genome biology · Jul 9, 2020Peer-reviewedGenetics