Vishnu Hosur

This study identifies redundant γc cytokines that enhance IL-1-driven neutrophil inflammation via MEK/ERK convergence, showing that blocking the shared γc receptor or MEK/ERK reduces disease severity.

This study optimizes the Cre-Lox system for efficient genome modification in mice by analyzing factors like loxP distance, Cre-driver strain, and breeding age.

This paper develops a method for efficient targeted transgenesis of large DNA constructs into multiple mouse genetic backgrounds using Bxb1 integrase, achieving high integration efficiency and precise insertion.

The paper shows that gene disruption strategies in mice can lead to unexpected exon skipping and translation, resulting in gain-of-function alleles instead of null phenotypes.

The paper shows ADAM17 is the main enzyme that removes the outer part of the AREG protein, which is important for skin health and cancer.