Neutralization and Stability of JN.1-derived LB.1, KP.2.3, KP.3 and KP.3.1.1 Subvariants
Pei Li, Julia N. Faraone, Cheng Chih Hsu, Michelle Chamblee, Yajie Liu, Yi-Min Zheng, Yan Xu, Claire Carlin, Jeffrey Craig Horowitz, Rama K. Mallampalli, Linda J. Saif, Eugene M. Oltz, Daniel M. Jones, Jiànróng Lǐ, Richard J. Gumina, , Shan‐Lu Liu
This study evaluates neutralization, infectivity, and stability of JN.1-derived SARS-CoV-2 subvariants, finding that DelS31 mutation in the NTD reduces nAb titers, impairs infectivity, and increases spike stability.
bioRxiv · Sep 4, 2024 · PreprintMolecular Biology