De novo rates of a Trypanosoma-resistant mutation in two human populations
Daniel Melamed, Revital Shemer, Evgeni Bolotin, Michael Bright Yakass, Dorit Fink-Barkai, Edem Kojo Hiadzi, Karl L. Skorecki, Adi Livnat
The paper measures de novo mutation rates of the APOL1 G1 1024A[->]G mutation in Africans and Europeans, finding it has the highest rate and is more common in Africans where it provides adaptive benefit.
Proceedings of the National Academy of Sciences · Aug 25, 2025Peer-reviewedEvolutionary Biology