Spinal cord and brain concentrations of riluzole after oral and intrathecal administration: a potential new treatment route for amyotrophic lateral sclerosis
Orion P. Keifer, Juanmarco Gutierrez, Mark T. Butt, Sarah D. Cramer, Raymond T. Bartus, Malú G. Tansey, Daniel R. Deaver, Alexandre Bétourné, Nicholas M. Boulis
This study evaluates intrathecal riluzole delivery in dogs to achieve spinal cord concentrations comparable to oral dosing without systemic side effects or elevated brain concentrations.
PLoS ONE · Aug 22, 2023Peer-reviewedNeuroscience