A randomized, controlled, two-center preclinical trial assessing the efficacy of a new benzodiazepine-dihydropyridine hybrid molecule (JM-20) in rodent models of ischemic stroke
Jeney Ramírez-Sánchez, André Rex, Sarah McCann, Daniel Schulze, Maylin Wong-Guerra, Luis A Fonseca-Fonseca, Enrique García-Alonso, Ailín Ramírez-Abreu, Ricardo Limonta, Monika Dopatka, Larissa Mosch, Yanier Núñez-Figueredo, Ulrich Dirnagl
This paper reports a two-center preclinical trial of JM-20, a benzodiazepine-dihydropyridine hybrid, showing modest neuroprotective effects in some rodent models of ischemic stroke but not in others.
bioRxiv · Mar 8, 2024 · PreprintPharmacology & Toxicology