Peripheral Htt silencing does not ameliorate central signs of disease in the B6. HttQ111/+ mouse model of Huntington’s Disease
Sydney R. Coffey, Robert M. Bragg, Shawn Minnig, Seth A. Ament, Jeffrey P. Cantle, Anne Glickenhaus, Daniel Shelnut, José M. Carrillo, Dominic D. Shuttleworth, Julie-Anne Rodier, Kimihiro Noguchi, C. Frank Bennett, Nathan D. Price, Holly B. Kordasiewicz, Jeffrey B. Carroll
This study shows that reducing huntingtin in peripheral organs of HD mice does not improve central nervous system disease signs.
PLoS ONE · Apr 28, 2017Peer-reviewedNeuroscience