A neuropeptide-specific signaling pathway for state-dependent regulation of the mesolimbic dopamine system
Mollie X. Bernstein, Omar Koita, Marta Trzeciak, Andrew Fan, Daniel T. McAuley, Seung‐Woo Jin, Larry S. Zweifel
This study identifies TRPC6 channels as mediators of neuropeptide-induced calcium signaling in VTA-DA neurons, showing state-dependent regulation of reward valuation and consummatory behavior.
bioRxiv · Jul 17, 2025 · PreprintNeuroscience