Remodeling of cholesterol metabolism in melanoma progression regulates nuclear membrane mechanics.
Michelle A. Baird, Daniela A. Malide, Christian A. Combs, Robert S Fischer, Clare M. Waterman
This study shows that cholesterol metabolism remodeling in melanoma progression alters nuclear membrane mechanics, increasing tension and vulnerability to rupture during cellular confinement.
bioRxiv · Sep 28, 2026 · PreprintCell Biology