Robert S Fischer

This study shows that cholesterol metabolism remodeling in melanoma progression alters nuclear membrane mechanics, increasing tension and vulnerability to rupture during cellular confinement.

This paper introduces an algorithm to reconstruct 3D molecular orientation and density from polarized fluorescence microscopy data, demonstrating its application on biological structures and dynamics.

The paper introduces a polarized dual-view light-sheet microscope to recover 3D orientations and positions of fluorescent dipoles, validated with experiments on biological samples.