How a highly acidic SH3 domain binds to its intrinsically disordered partner through the formation of an encounter complex intermediate
Valeria Jaramillo‐Martinez, Ritika Kukreja, Michaela R. Cohen, Ally F. Mujica, Samuel Barton, Oluebube C. Onwuzulu, Jorge I. Cardoso, Matthew J. Dominguez, Isabelle M. Kekwick, Jaden Ali, Gemma M. Bell, Sydney J. Rice, Daniela Poaquiza, Colin McClure, Frida Anguiano, , Elliott J. Stollar
The paper investigates how the highly acidic SH3 domain binds to an intrinsically disordered partner through an encounter complex intermediate, revealing the role of long-range electrostatic interactions.
The Journal of Physical Chemistry B · Oct 5, 2026Peer-reviewedBiophysics