Valeria Jaramillo‐Martinez

How a highly acidic SH3 domain binds to its intrinsically disordered partner through the formation of an encounter complex intermediate

The paper investigates how the highly acidic SH3 domain binds to an intrinsically disordered partner through an encounter complex intermediate, revealing the role of long-range electrostatic interactions.

A dual sensor regulates P-glycoproteins structural plasticity

The paper uses cryo-EM to study P-glycoprotein in different environments, revealing distinct roles of transmembrane helices 4 and 10 in its functional plasticity.

Molecular phenotypes segregate missense mutations in SLC13A5 Epilepsy

The paper classifies molecular defects of six SLC13A5 mutations into two classes, revealing distinct mechanisms of impaired citrate transport and protein folding, with implications for targeted therapies.