Histone demethylase enzymes KDM5A and KDM5B modulate immune response by suppressing transcription of endogenous retroviral elements
Huadong Chen, Letitia Sarah, Daniela Pucciarelli, Ying Mao, Morgan E. Diolaiti, Danica Galonić Fujimori, Alan Ashworth
This study shows KDM5A and KDM5B regulate ERV expression and immune response by modulating KRAB-ZNF genes, with degradation of KDM5A causing rapid ERV activation.
bioRxiv · Sep 23, 2024 · PreprintGenomics