Ying Qing Mao

The paper links heart rate dynamics to brain functional organization and cognitive traits using multi-modal data and statistical analysis.

This paper develops a method to selectively kill cancer cells with TP53 mutations by using RNA-guided Cas12a2 to induce chromatin shredding through targeting cancer-specific transcripts.

This paper introduces HS2PM, a two-photon microscope that enables kilohertz-rate imaging of neuronal populations in vivo, revealing voltage dynamics and their role in sensory adaptation and population coding.

This study identifies DDIT4L as an inhibitor of glioblastoma by suppressing mitochondrial function and inducing apoptosis, with a synthetic peptide showing therapeutic potential.

The paper introduces LetsACT, a multimodal integration platform that combines morphological, spatial, and transcriptomic data to analyze morpho-genetic variations in human cortical neurons associated with tumor infiltration.

This paper introduces a compact two-photon imaging module that enables simultaneous dual-depth, multi-region in vivo brain imaging, revealing context-dependent and depth-divergent neural activity patterns.

The paper creates a spatially-resolved human brain proteome atlas, revealing protein diversity and functional specialization, and identifies therapeutic targets in epilepsy.

This study creates a single-cell spatial transcriptomic atlas of the human cortex, revealing gene expression patterns, aging effects, and disease associations across layers and species.

The paper introduces Meso2P, a two-photon imaging platform that enables high-resolution, large-scale volumetric imaging of the cortex with modular upgrades for multi-plane and optogenetic stimulation.

This study identifies DDIT4L intron retention (DIR) as a contributor to cognitive impairment and amyloid plaque formation in Alzheimer's disease through interactions with gelsolin and GluA1.

This study shows KDM5A and KDM5B regulate ERV expression and immune response by modulating KRAB-ZNF genes, with degradation of KDM5A causing rapid ERV activation.

This study shows that microglia replacement through bone marrow transplantation halts disease progression in both mouse models and human patients with ALSP.

The paper investigates the role and mechanisms of leptomeningeal collaterals in human distal MCA territory ischemia using experimental and computational methods.

The paper identifies that co-activation of the ventral posterolateral nucleus and global brain activity correlates with physiological arousal but not perceptual awareness.

This study shows that microglia facilitate and stabilize the general anesthesia response by activating P2Y12 and calcium influx, without involving dendritic spine plasticity.

The paper identifies cortical hubs associated with consciousness recovery in UWS patients and finds the anterior precuneus is a key region.

The paper identifies higher-order sensorimotor brain hubs that correlate with consciousness levels across different unconscious states using resting-state fMRI data.

This paper investigates the hybrid nature of task-evoked neural activity using intracranial EEG and Deep Learning LSTM models, showing that poststimulus activity is influenced more by prestimulus dynamics than the external stimulus itself.

This paper develops a non-viral CRISPR-Cas9 system for precise genome editing in human T cells, enabling therapeutic reprogramming of cell function and specificity.

The paper introduces a theory of neural coding based on self-information principles and demonstrates its application in identifying cell-assembly patterns across various brain activities.

The paper shows spike-timing patterns across different neurons and species follow a gamma-distribution, remain stable across cognitive states, and break down under anesthesia.