Hairpin Architecture and Extended Sequence Context Shape APOBEC3 Mutagenesis in Monkeypox Virus at Different Genomic Scales
Alexandra V Madorskaya, Fedor M. Kazanov, Danila A Bogdanov, Gennady V. Ponomarev, A. V. Smol'nikova, Daria V. Garshina, Evgenii V. Matveev, Ruslan Kh. Abasov, Cem Azgari, Ogün Adebalı, Dmitry N. Ivankov, Mikhail Sergeevich Gelfand, Marat D. Kazanov
The paper reanalyzes APOBEC3 mutagenesis in MPXV genomes, showing mutations are enriched at TC motifs in hairpin loops and downstream guanine-rich sequences, with structural and sequence context playing distinct roles at different genomic scales.
bioRxiv · Oct 6, 2026 · PreprintMicrobiology