Marat D. Kazanov

The paper reanalyzes APOBEC3 mutagenesis in MPXV genomes, showing mutations are enriched at TC motifs in hairpin loops and downstream guanine-rich sequences, with structural and sequence context playing distinct roles at different genomic scales.

The paper identifies APOBEC3A as the main RNA editor in human cells and viruses, showing its preference for specific motifs in mRNA and viral RNA.

The paper reanalyzes MPXV mutation data and finds no statistically significant enrichment of APOBEC-signature mutations in cruciform structures formed by inverted repeats.

The paper analyzes MPXV RNA-seq data to determine if APOBEC3 enzymes edit viral RNA, concluding that observed mutations result from DNA-level mutagenesis, not RNA editing.

This study reconstructs carbohydrate utilization pathways in human gut bifidobacteria, revealing strain-specific metabolic capabilities and validating them experimentally.

The paper analyzes whole-genome sequencing data from cancer samples to identify genomic footprints of telomere maintenance mechanisms, finding specific telomere variant repeat patterns associated with ATRX/DAXX mutations.

The paper examines how somatic structural variations affect TAD boundaries and gene regulation in human cancers using whole genome sequencing data.

This study analyzes chromothripsis in 2,658 cancers using whole-genome sequencing, finding it prevalent across multiple cancer types with complex structural alterations.