Fedor M. Kazanov

The paper reanalyzes APOBEC3 mutagenesis in MPXV genomes, showing mutations are enriched at TC motifs in hairpin loops and downstream guanine-rich sequences, with structural and sequence context playing distinct roles at different genomic scales.

The paper reanalyzes MPXV mutation data and finds no statistically significant enrichment of APOBEC-signature mutations in cruciform structures formed by inverted repeats.

The paper analyzes MPXV RNA-seq data to determine if APOBEC3 enzymes edit viral RNA, concluding that observed mutations result from DNA-level mutagenesis, not RNA editing.