Sequence Composition Dictates Condensate Miscibility
Gaofeng Pei, Xinxin Wang, Danqian Geng, Zhuo Chen, Weifan Xu, Tingting Li, Pilong Li
The paper investigates how amino acid composition affects biomolecular condensate miscibility and shows that serine-rich or aromatic IDRs form miscible condensates, while highly charged IDRs form immiscible ones, with phosphorylation modulating this behavior.
bioRxiv · Nov 29, 2024 · PreprintMolecular Biology