Pilong Li

Z-RNA-ZBP1 axis drives Tau-mediated neurodegeneration

The paper identifies the Z-RNA-ZBP1 axis as a driver of Tau-mediated neurodegeneration and shows that ZBP1 inhibition can alleviate cognitive deficits in Tau-transgenic mice.

Mapping Core Components of Membrane-less Organelles in Living Cells by Phase-APEX2 Proximity Labeling

The paper introduces Phase-APEX2, a method to specifically label membrane-less organelles, revealing their core components and molecular mechanisms.

Comparative Temporal Transcriptomic Analysis of SOD1 Mutations in iPSC-Motor Neurons

This study compares temporal transcriptomic changes in iPSC-derived motor neurons with SOD1 mutations D91A and G94A to understand their impact on ALS severity.

Novel Strategy against AML by Rescuing Loss of Phase Separation of Pathogenic NPM1c

This study identifies a small molecule that rescues NPM1c phase separation loss, restoring nucleolar localization and showing anti-leukemia activity in AML models.

Sequence Composition Dictates Condensate Miscibility

The paper investigates how amino acid composition affects biomolecular condensate miscibility and shows that serine-rich or aromatic IDRs form miscible condensates, while highly charged IDRs form immiscible ones, with phosphorylation modulating this behavior.

PHF1 compartmentalizes PRC2 at target loci via phase separation

This study shows PHF1 forms phase-separated condensates that recruit PRC2 to target loci, facilitating H3K27me3 deposition and transcription repression.

L1 and B1 repeats blueprint the spatial organization of chromatin

This study identifies L1 and B1 retrotransposons as key elements shaping the 3D chromatin structure through spatial compartmentalization in human and mouse cells.