Crowdsourcing: Spatial clustering of low-affinity binding sites amplifies in vivo transcription factor occupancy
Justin Malin, Daphne Ezer, Xiaoyan Ma, Steve Mount, Hiren Karathia, Seung Gu Park, Boris Adryan, Sridhar Hannenhalli
The paper shows that spatial clustering of low-affinity TF binding sites increases their in vivo occupancy through cooperative effects, with tissue-specific scaling and motif-dependent impacts.
bioRxiv · Aug 12, 2015 · PreprintGenomics