Conserved cis and trans communication domains mediate module interaction in glycopeptide antibiotic NRPS assembly lines
Thomas Michael Hamm, Dardan Beqaj, Nina Pfahler, Andreas Kulik, Thilo Stehle, Wolfgang Wohlleben, Evi Stegmann
The paper identifies trans- and cis-COM domains in NRPS systems that mediate enzyme communication, revealing a unified model for maintaining assembly line fidelity in glycopeptide antibiotic biosynthesis.
bioRxiv · Sep 11, 2026 · PreprintMicrobiology