Beyond the myosin mesa: a potential unifying hypothesis on the underlying molecular basis of hyper-contractility caused by a majority of hypertrophic cardiomyopathy mutations
Suman Nag, Darshan V Trivedi, Saswata S Sarkar, Shirley Sutton, Kathleen M Ruppel, James A Spudich
This paper proposes a unifying hypothesis that hypertrophic cardiomyopathy mutations increase functionally accessible myosin heads in the sarcomere, leading to hyper-contractility.
bioRxiv · Jul 24, 2016Biochemistry