HNRNPM controls circRNA biogenesis and splicing fidelity to sustain prostate cancer cell fitness
Jessica Ho, Federico Di Tullio, Megan Catherine Schwarz, Diana H. P. Low, Danny Incarnato, Florence P. H. Gay, Tommaso Tabaglio, Jingxian Zhang, Heike Wollmann, Leilei Chen, Ömer An, Tim Hon Man Chan, Alexander Hall Hickman, Simin Zheng, Vladimir Roudko, , Ernesto Guccione
This study identifies HNRNPM as a splicing factor critical for prostate cancer cell growth by regulating splicing fidelity and circRNA biogenesis, suggesting it as a therapeutic target.
eLife · Jun 2, 2021Peer-reviewedGenomics