Eva Hernando

The paper identifies progranulin as a mediator of immune suppressive niches in brain metastasis using cross-species spatial transcriptomics and functional analyses.

This study shows that chromatin architecture and physical constriction together drive phenotype switching and metastasis in melanoma by altering CTCF positioning and heterochromatin structure.

This study identifies HOXD13 as a driver of a developmental program in melanoma that promotes angiogenesis and suppresses T-cell infiltration through a gene regulatory axis involving VEGFA, SEMA3A, and CD73.

This study identifies CNDP1 as a metabolic vulnerability in brain metastasis, showing its inhibition suppresses metastasis and its expression confers metastatic potential.

The paper identifies miRNAs that upregulate CD98hc and ST3GAL1/ST3GAL2 in melanoma, revealing a bidirectional regulatory mechanism in miRNA networks.

The paper improves somatic mutation detection in tumor samples without matched normal samples by estimating tumor purity and variant allele frequency, reducing false positive and negative rates.

The paper identifies shared transcriptomic features between melanoma brain metastases and neurodegenerative diseases, highlighting key genes and providing an open-source tool for analysis.

This study identifies HNRNPM as a splicing factor critical for prostate cancer cell growth by regulating splicing fidelity and circRNA biogenesis, suggesting it as a therapeutic target.