Higher-order epistatic networks underlie the evolutionary fitness landscape of a xenobiotic- degrading enzyme
Gloria Yang, Dave W Anderson, Florian Baier, Elias Dohmen, Nansook Hong, Paul D Carr, Shina Caroline Lynn Kamerlin, Colin J Jackson, Erich Bornberg-Bauer, Nobuhiko Tokuriki
This study identifies five mutations that enable the evolution of a xenobiotic-degrading enzyme and shows that higher-order epistasis shapes its adaptive landscape and substrate specificity.
bioRxiv · Dec 26, 2018 · PreprintBiochemistry