Author

Paul D Carr

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:protein sequence· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Florian Baier· 2 shared Gloria Yang· 2 shared Nansook Hong· 2 shared Alexandre Barrozo· 1 shared Anna Pabis· 1 shared Colin J JacksoniD· 1 shared Colin J Jackson· 1 shared Dave W Anderson· 1 shared

Activity by Year

2017-2018 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Florian Baier

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2 papers

Recent·Most cited

Higher-order epistatic networks underlie the evolutionary fitness landscape of a xenobiotic- degrading enzyme

Gloria Yang, Dave W Anderson, Florian Baier, Elias Dohmen, Nansook Hong, Paul D Carr, Shina Caroline Lynn Kamerlin, Colin J Jackson, Erich Bornberg-Bauer, Nobuhiko Tokuriki

This study identifies five mutations that enable the evolution of a xenobiotic-degrading enzyme and shows that higher-order epistasis shapes its adaptive landscape and substrate specificity.

bioRxiv · Dec 26, 2018 · PreprintBiochemistry

Cryptic genetic variation defines the adaptive evolutionary potential of enzymes

Florian Baier, Nansook Hong, Gloria Yang, Anna Pabis, Alexandre Barrozo, Paul D Carr, Shina CL Kamerlin, Colin J Jackson, Nobuhiko Tokuriki

This study shows that genetic variation in enzymes leads to different evolutionary outcomes depending on initial activity levels and molecular properties.

bioRxiv · Dec 12, 2017 · PreprintEvolutionary Biology