Atomic structure of Hsp90:Cdc37:Cdk4 reveals Hsp90 regulates kinase via dramatic unfolding
Kliment A Verba, Ray YR Wang, Akihiko Arakawa, Yanxin Liu, Mikako Shirouzu, Shigeyuki Yokoyama, David A Agard
The paper reports the first structure of a Hsp90:Cdc37:Cdk4 complex, revealing Hsp90 stabilizes kinases by trapping them in an unfolded state.
bioRxiv · Mar 4, 2016Biochemistry