The impact of chromatin dynamics on Cas9-mediated genome editing in human cells
Rene M. Daer, Josh P. Cutts, David A. Brafman, Karmella Haynes
This study investigates how chromatin dynamics affect Cas9-mediated genome editing in human cells and shows that closed chromatin inhibits editing, which can be reversed to restore efficiency.
bioRxiv · Aug 25, 2016Synthetic Biology