Reversibility of chemotherapy-induced senescence is independent of autophagy and a potential model for tumor dormancy and cancer recurrence.
Tareq Saleh, Emmanuel K. Cudjoe, S. Lauren Kyte, Scott C. Henderson, Lynne W. Elmore, David A. Gewirtz
This study shows chemotherapy-induced senescence in tumor cells can be reversed without autophagy, suggesting senescence may be transient and linked to cancer recurrence.
bioRxiv · Jan 11, 2017 · PreprintCancer Biology