Comprehensive interrogation of human skeletal muscle reveals a dissociation between insulin resistance and mitochondrial capacity
Katie L. Whytock, Maria F. Pino, Yifei Sun, Gongxin Yu, Flávia Giolo de Carvalho, Reichelle X. Yeo, Rick B. Vega, Gaganvir Parmar, Adeline Divoux, N Kapoor, Fancaho Yi, Heather Cornnell, David A. Patten, Mary‐Ellen Harper, Stephen J. Gardell, , Lauren Marie Sparks
This study compares mitochondrial capacity and related molecular features in skeletal muscle across lean active, obese, and obese-insulin resistant T2D individuals, finding no difference between obese with and without T2D but higher capacity in lean active individuals.
American Journal of Physiology-Endocrinology and Metabolism · Aug 16, 2023Peer-reviewedMolecular Biology