Mary‐Ellen Harper

This study examines metabolic changes in brown adipose tissue during cold deacclimation, identifying rapid adaptations in N-acetylated amino acid metabolism.

The paper investigates OPA1's role in cardiac function and metabolism using in silico and in vivo approaches, finding that OPA1 overexpression improves cardiac function and maintains metabolic markers in a mouse model.

The paper develops a hybrid machine learning framework to annotate genes involved in mitochondrial glutathione metabolism and transport in cancers, identifying potential targets and demonstrating high predictive performance.

This study compares mitochondrial capacity and related molecular features in skeletal muscle across lean active, obese, and obese-insulin resistant T2D individuals, finding no difference between obese with and without T2D but higher capacity in lean active individuals.

This paper introduces a Bayesian method to map protein abundance QTLs in plasma, identifying replicated associations and demonstrating increased statistical power over univariate approaches.

This study shows that parkin reduces oxidative stress in mammalian brains by mediating H2O2 reduction and glutathione regeneration, but its absence leads to increased oxidative stress despite compensatory mechanisms.