Single-molecule imaging of telomerase RNA reveals a Recruitment-Retention model for telomere elongation
Hadrien Laprade, Emmanuelle Querido, Michael J. Smith, David Guérit, Hannah Crimmins, Dimitri Conomos, Emilie Pourret, Pascal Chartrand, Agnel J. Sfeir
This study uses single-molecule imaging to reveal a Recruitment-Retention model for telomere elongation, showing how hTERT and TPP1 regulate hTR dynamics and how mutations affect telomere homeostasis.
Molecular Cell · Jun 3, 2020Peer-reviewedMolecular Biology