CpG islands act as topological sinks for transcription-induced DNA supercoiling
Catherine Naughton, Andrea Bonato, Michael Chiang, Samuel Corless, Jon Stocks, Graeme R. Grimes, David Halliday, Alessandro Bentivoglio, Chris A. Brackley, Davide Marenduzzo, Nick Gilbert
The paper shows CpG islands act as topological sinks for transcription-induced DNA supercoiling by focusing torsional stress and promoting DNA melting.
bioRxiv · Aug 25, 2026 · PreprintMolecular Biology