Michael Chiang

The paper compares two scRNA-seq platforms to quantify transcriptional noise and identifies gene length and CpG-island promoters as factors influencing noise levels.

The paper shows that nucleosome positioning determines chromatin's physical state, with irregular positioning enabling accessibility for transcription while maintaining genome protection.

The paper shows CpG islands act as topological sinks for transcription-induced DNA supercoiling by focusing torsional stress and promoting DNA melting.

This paper shows that RNA and SAF-A form a microgel network in the nucleus near the sol-gel transition, exhibiting viscoelastic properties and reconciling solid-like and fluid-like behaviors.

The paper uses simulations to link 3D gene structure with transcription noise in human chromosomes, showing structural heterogeneity drives gene expression variability.

The paper shows RNA polymerase II is necessary for spatial chromatin reorganization after mitosis, as demonstrated by Hi-C and in silico modeling.