Allosteric modulation of β1 integrin through the hybrid domain reverses articular cartilage injury and functional impairment in a murine model of inflammatory arthritis
Rehab AlJamal-Naylor, Nicola Jane Barton, Susan McIntyre, Daniel S. McQueen, David J Harrison
This study shows that allosteric modulation of β1 integrin through its hybrid domain protects cartilage and reduces inflammation in a mouse model of arthritis.
bioRxiv · Jul 15, 2026 · PreprintPharmacology & Toxicology