IGFBP2 protects against pulmonary fibrosis through inhibiting P21-mediated senescence
Chiahsuan Chin, John Lee, Ranjith Ravichandran, Timothy P. Fleming, Stephen Bentley Wheatcroft, Mark T. Kearney, Ross Macrae Bremner, Thalachallour Mohanakumar, David J. Flint, Angara Sureshbabu
This study shows that IGFBP2 inhibits senescence and pulmonary fibrosis by suppressing P21 in aged mice, with epigenetic downregulation of Igfbp2 contributing to fibrosis.
bioRxiv · Jan 21, 2021 · PreprintMolecular Biology