Mark T. Kearney

This study examines the relationship between heart rate, sympathetic activation, and the force-frequency relationship in HFrEF patients and controls, finding a bidirectional link with optimal heart rate targets likely being individual.

The paper examines transcriptomic heterogeneity of microvascular endothelial cells in subcutaneous adipose tissue and skeletal muscle in type 2 diabetes, finding stress in SAT but not SkM.

This study examines how murine limb ischaemia affects bone marrow structure and function, revealing both local and systemic changes in haematopoiesis and myeloid cell function.

This paper identifies a small molecule that reduces IR:IGF-1R hybrid formation in human endothelial cells, increasing Akt phosphorylation and altering PI3-kinase signaling.

The paper uses site-directed mutagenesis to identify key residues involved in IR-IGF1R hybrid receptor formation, showing mutations reduce hybrid affinity and support rational drug design.

This study shows that IGFBP2 inhibits senescence and pulmonary fibrosis by suppressing P21 in aged mice, with epigenetic downregulation of Igfbp2 contributing to fibrosis.