Early nuclear phenotypes and reactive transformation in human iPSC-derived astrocytes from ALS patients with SOD1 mutations
Vincent Soubannier, Mathilde Chaineau, Lale Gursu, Sarah Lépine, David Kalaydjian, Ghazal Haghi, Guy Armand Rouleau, Thomas M. Durcan, Stefano Stifani
This study identifies early nuclear phenotypes in SOD1-mutated astrocytes derived from ALS patients that precede reactive transformation and may affect astrocyte-MN communication.
bioRxiv · Oct 5, 2023 · PreprintNeuroscience