Vincent Soubannier

A validated antibody toolbox for ALS research

The paper establishes a validated antibody platform for ALS research, identifying high-quality antibodies and revealing protein expression patterns in neurological cell types.

Early nuclear phenotypes and reactive transformation in human iPSC-derived astrocytes from ALS patients with SOD1 mutations

This study identifies early nuclear phenotypes in SOD1-mutated astrocytes derived from ALS patients that precede reactive transformation and may affect astrocyte-MN communication.

Transcriptional dysregulation and impaired neuronal activity in FMR1 knock-out and Fragile X patients iPSC-derived models.

This study compares FMR1 knock-out and Fragile X patient iPSC-derived neuronal models, finding shared transcriptional and functional impairments in neuronal activity and differentiation.

CelltypeR: A flow cytometry pipeline to annotate, characterize and isolate single cells from brain organoids

The paper develops a flow cytometry pipeline called CelltypeR to annotate and characterize cell types in brain organoids, identifying dopamine neuron subtypes and tracking cell type dynamics over time.

Rapid generation of ventral spinal cord-like astrocytes from human iPSCs for modeling non-cell autonomous mechanisms of lower motor neuron disease

This study develops a method to rapidly generate ventral spinal cord-like astrocytes from human iPSCs to model lower motor neuron disease mechanisms.

Midbrain organoids with an SNCA gene triplication model key features of synucleinopathy

This study uses midbrain organoids from SNCA triplication patients to model synucleinopathy features, showing increased alpha-synuclein expression and aggregation linked to dopaminergic neuron loss.

Characterization of human iPSC-derived astrocytes with potential for disease modeling and drug discovery

This study derives and characterizes human iPSC-derived astrocytes, showing they exhibit physiological traits and respond to inflammatory stimuli, making them suitable for disease modeling and drug discovery.