Author

David L. Penkler

Rhodes University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:protein structure· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein structure prediction· 1 Approach:simulation· 1

Frequent Co-Authors

Özlem Taştan BishopiD· 2 shared Canan AtılganiD· 1 shared

Activity by Year

2018-2019 · peak 1/yr

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2 top collaborators · 1 mutual co-author link

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2 shared papersBioinformatics

Özlem Taştan BishopORCID

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2 papers

Recent·Most cited

Modulation of Human Hsp90α Conformational Dynamics by Allosteric Ligand Interaction at the C-Terminal Domain

David L. Penkler, Özlem Taştan Bishop

The paper identifies three natural compound allosteric modulators of Hsp90 and assesses their effect on the protein's conformational dynamics.

Scientific Reports · Feb 7, 2019Peer-reviewedBioinformatics

Allosteric Modulation of Conformational Dynamics in Human Hsp90α: A Computational Study

David L. Penkler, Canan Atılgan, Özlem Taştan Bishop

This study uses computational methods to analyze how ATP and ADP affect the conformational dynamics of human Hsp90, identifying key residues involved in allosteric modulation.

Journal of Chemical Information and Modeling · Jan 29, 2018Peer-reviewedBioinformatics